Journal

Matte 3D hexagonal molecular lattice sphere in teal

What Is Histamine Intolerance? A Practitioner's Guide to Symptoms, Root Causes, and Natural Support

Nathalie Babazadeh 10 min read

Quick answer Histamine intolerance develops when your body accumulates more histamine than it can break down, usually due to reduced DAO enzyme activity, gut dysbiosis, or liver congestion. It is...

What Is Histamine Intolerance? A Practitioner's Guide to Symptoms, Root Causes, and Natural Support

Nathalie Babazadeh 10 min read

Quick answer Histamine intolerance develops when your body accumulates more histamine than it can break down, usually due to reduced DAO enzyme activity, gut dysbiosis, or liver congestion. It is...

Matte 3D key-and-lock enzyme mechanism in teal and amber

The DAO Enzyme: Why Some People Can't Break Down Histamine

Felix Christmann 7 min read

Quick answer Diamine oxidase (DAO) is the enzyme in your gut lining that breaks down histamine from food before it enters your bloodstream. When DAO activity is low — from...

The DAO Enzyme: Why Some People Can't Break Down Histamine

Felix Christmann 7 min read

Quick answer Diamine oxidase (DAO) is the enzyme in your gut lining that breaks down histamine from food before it enters your bloodstream. When DAO activity is low — from...

Matte 3D stinging nettle leaf floating on clean white background

Stinging Nettle: Why This 'Weed' Is in Longevity Protocols

Nathalie Babazadeh 7 min read

Quick answer Stinging nettle modulates the histamine system at multiple points: influencing H1 receptor expression, inhibiting tryptase, and reducing pro-inflammatory cytokines. It also provides bioavailable iron, silica, calcium, and magnesium....

Stinging Nettle: Why This 'Weed' Is in Longevity Protocols

Nathalie Babazadeh 7 min read

Quick answer Stinging nettle modulates the histamine system at multiple points: influencing H1 receptor expression, inhibiting tryptase, and reducing pro-inflammatory cytokines. It also provides bioavailable iron, silica, calcium, and magnesium....

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Quercetin vs. Cromolyn for Mast Cell Support: What the Research Shows

Kacey Moe 5 min read

Quick answer Both quercetin and cromolyn stabilize mast cells, but through different mechanisms. A 2012 study found quercetin more effective at inhibiting cytokine release. Quercetin works systemically and is available...

Quercetin vs. Cromolyn for Mast Cell Support: What the Research Shows

Kacey Moe 5 min read

Quick answer Both quercetin and cromolyn stabilize mast cells, but through different mechanisms. A 2012 study found quercetin more effective at inhibiting cytokine release. Quercetin works systemically and is available...

Matte 3D teal sphere releasing golden histamine particles

Mast Cell Activation: What Your Immune System Is Actually Doing

Felix Christmann 11 min read

Quick answer Mast cells are immune sentinels loaded with over 200 chemical mediators (histamine is just one). When they become chronically hyperreactive — activating in response to stress, foods, heat,...

Mast Cell Activation: What Your Immune System Is Actually Doing

Felix Christmann 11 min read

Quick answer Mast cells are immune sentinels loaded with over 200 chemical mediators (histamine is just one). When they become chronically hyperreactive — activating in response to stress, foods, heat,...

Matte 3D render of gut and brain connected by neural pathway, coral and teal

Histamine and Gut Health: The Connection Most People Miss

Felix Christmann 9 min read

Quick answer Your gut is the epicenter of histamine metabolism. It is where DAO enzyme breaks down dietary histamine, where bacteria produce additional histamine, and where the densest population of...

Histamine and Gut Health: The Connection Most People Miss

Felix Christmann 9 min read

Quick answer Your gut is the epicenter of histamine metabolism. It is where DAO enzyme breaks down dietary histamine, where bacteria produce additional histamine, and where the densest population of...

Matte 3D amber wine glass tipped on its side with teal histamine molecules spilling out

Why That Glass of Wine Gives You a Stuffy Nose (And What Your Body Is Actually Telling You)

Nathalie 6 min read

Quick answer Wine flushing and congestion are histamine responses, not allergies. Red wine delivers histamine from fermentation AND triggers your mast cells to release more, while alcohol suppresses DAO, the...

Why That Glass of Wine Gives You a Stuffy Nose (And What Your Body Is Actually Telling You)

Nathalie 6 min read

Quick answer Wine flushing and congestion are histamine responses, not allergies. Red wine delivers histamine from fermentation AND triggers your mast cells to release more, while alcohol suppresses DAO, the...