Journal
How histamine pathways, mast cell activation, and immune modulation work — and what practitioners use to support them.
What Is Histamine Intolerance? A Practitioner's Guide to Symptoms, Root Causes, and Natural Support
Quick answer Histamine intolerance develops when your body accumulates more histamine than it can break down, usually due to reduced DAO enzyme activity, gut dysbiosis, or liver congestion. It is...
What Is Histamine Intolerance? A Practitioner's Guide to Symptoms, Root Causes, and Natural Support
Quick answer Histamine intolerance develops when your body accumulates more histamine than it can break down, usually due to reduced DAO enzyme activity, gut dysbiosis, or liver congestion. It is...
The DAO Enzyme: Why Some People Can't Break Down Histamine
Quick answer Diamine oxidase (DAO) is the enzyme in your gut lining that breaks down histamine from food before it enters your bloodstream. When DAO activity is low — from...
The DAO Enzyme: Why Some People Can't Break Down Histamine
Quick answer Diamine oxidase (DAO) is the enzyme in your gut lining that breaks down histamine from food before it enters your bloodstream. When DAO activity is low — from...
Stinging Nettle: Why This 'Weed' Is in Longevity Protocols
Quick answer Stinging nettle modulates the histamine system at multiple points: influencing H1 receptor expression, inhibiting tryptase, and reducing pro-inflammatory cytokines. It also provides bioavailable iron, silica, calcium, and magnesium....
Stinging Nettle: Why This 'Weed' Is in Longevity Protocols
Quick answer Stinging nettle modulates the histamine system at multiple points: influencing H1 receptor expression, inhibiting tryptase, and reducing pro-inflammatory cytokines. It also provides bioavailable iron, silica, calcium, and magnesium....
Quercetin vs. Cromolyn for Mast Cell Support: What the Research Shows
Quick answer Both quercetin and cromolyn stabilize mast cells, but through different mechanisms. A 2012 study found quercetin more effective at inhibiting cytokine release. Quercetin works systemically and is available...
Quercetin vs. Cromolyn for Mast Cell Support: What the Research Shows
Quick answer Both quercetin and cromolyn stabilize mast cells, but through different mechanisms. A 2012 study found quercetin more effective at inhibiting cytokine release. Quercetin works systemically and is available...
Mast Cell Activation: What Your Immune System Is Actually Doing
Quick answer Mast cells are immune sentinels loaded with over 200 chemical mediators (histamine is just one). When they become chronically hyperreactive — activating in response to stress, foods, heat,...
Mast Cell Activation: What Your Immune System Is Actually Doing
Quick answer Mast cells are immune sentinels loaded with over 200 chemical mediators (histamine is just one). When they become chronically hyperreactive — activating in response to stress, foods, heat,...
Histamine and Gut Health: The Connection Most People Miss
Quick answer Your gut is the epicenter of histamine metabolism. It is where DAO enzyme breaks down dietary histamine, where bacteria produce additional histamine, and where the densest population of...
Histamine and Gut Health: The Connection Most People Miss
Quick answer Your gut is the epicenter of histamine metabolism. It is where DAO enzyme breaks down dietary histamine, where bacteria produce additional histamine, and where the densest population of...
The Complete Immune Resilience Protocol: A Practitioner's Stack
Quick answer A practitioner immune protocol starts with Lucidia's five ingredients for core immune regulation (mast cell stabilization, glutathione support, immune modulation), then layers in vitamin D3/K2, zinc, vitamin C,...
The Complete Immune Resilience Protocol: A Practitioner's Stack
Quick answer A practitioner immune protocol starts with Lucidia's five ingredients for core immune regulation (mast cell stabilization, glutathione support, immune modulation), then layers in vitamin D3/K2, zinc, vitamin C,...
Bromelain: The Inflammation-Clearing Enzyme You're Probably Missing
Quick answer Bromelain is a group of proteolytic enzymes from pineapple stems that break down inflammatory proteins, support lymphatic drainage, and improve quercetin absorption. Take it on an empty stomach...
Bromelain: The Inflammation-Clearing Enzyme You're Probably Missing
Quick answer Bromelain is a group of proteolytic enzymes from pineapple stems that break down inflammatory proteins, support lymphatic drainage, and improve quercetin absorption. Take it on an empty stomach...
The Longevity Science Behind Lucidia's Five Ingredients
Quick answer Lucidia combines quercetin (senolytic, mast cell stabilizer), NAC (glutathione precursor), reishi (immunomodulator), bromelain (absorption enhancer, anti-inflammatory enzyme), and stinging nettles (histamine pathway modulator). Together they cover detoxification, immune...
The Longevity Science Behind Lucidia's Five Ingredients
Quick answer Lucidia combines quercetin (senolytic, mast cell stabilizer), NAC (glutathione precursor), reishi (immunomodulator), bromelain (absorption enhancer, anti-inflammatory enzyme), and stinging nettles (histamine pathway modulator). Together they cover detoxification, immune...